Orochimaru is one of the most feared villains in the Naruto series, because of his sinister experiments and near-immortality. Orochimaru boasts a great deal of knowledge in ninjutsu, and his relentless pursuit makes him formidable. However, in the anime world, there's so much more talent that seriously outclasses even Orochimaru's.
From reality-bending abilities to godlike strength, these characters would make Orochimaru take the fall with a single flick without breaking a sweat. These characters have overwhelming force, supernatural abilities, or intelligence and Orochimaru wouldn't stand a chance against them. Gojo, Saitma and Aizen are some of the anime characters who can defeat Orochimaru.
Disclaimer: This list is ranked in no particular order and contains the writer's opinion.
Gojo Satoru, Meruem, and 8 other anime characters who can easily beat Orochimaru from Naruto
1) Saitama (One Punch Man)

Saitama is the main protagonist in One Punch Man, with overwhelmingly superior strength to knock down anyone in a single punch, no matter how accomplished they are. Huge knowledge in ninjutsu, regeneration, and cunning tactics that Orochimaru possessed are helpless against this strongest power of Saitama.
Saitama's speed and durability would also render it impossible for Orochimaru to achieve a meaningful attack. In turn, his deadliest techniques like Edo Tensei would also prove futile because the power level of Saitama oversteps all limits of defense. This makes Saitama one of the anime characters who can beat Orochimaru from Naruto.
2) Lelouch vi Britannia (Code Geass)

Lelouch vi Britannia from Code Geass leads into the powerful Geass ability known as the "Power of Absolute Obedience." This allows him to command anyone to do something impossible or deadly with just one look into his eyes. An ability such as this against Orochimaru would allow for his control over the man's actions in an instant, rendering him helpless.
Lelouch would win easily against him, simply by ordering him to stop moving, self-destruct, or surrender, using his Geass on him without having to engage in any form of combat. His strategic genius would make him one of the anime characters who can effortlessly defeat Orochimaru from Naruto.
3) Aizen (Bleach)

Aizen from Bleach is a character of overwhelming power and intellect who would overpower Orochimaru from Naruto. His Zanpakuto, Kyoka Suigetsu, can manipulate all five senses of his opponent by completely hypnotizing him.
A person affected would not tell reality from illusion, and thus any counterattacks would be vain attempts. Besides, Aizen's huge spiritual pressure and regeneration, and his transformation into a transcendent being further sealed his superiority and left Orochimaru completely powerless in front of him.
4) Gojo Satoru (Jujutsu Kaisen)

Gojo Satoru of Jujutsu Kaisen is an overwhelmingly powerful sorcerer whose Limitless technique and Six Eyes make him nearly invincible. His Infinity creates a tight shield that no attack can permeate, therefore meaning Orochimaru could not touch a single hair on his head.
Furthermore, Gojo's Domain Extension-Infinate Void completely incapacitates his opponents with their senses overloaded. With these abilities, Gojo could effortlessly defeat Orochimaru from Naruto, neutralizing him before he even has a chance to fight back.
5) Meruem (Hunter x Hunter)

Meruem from Hunter x Hunter can easily crush Orochimaru because of his vastly superior strength and speed. Being the Chimera Ant King, Meruem has physical abilities that would make him very formidable among his opponents.
In addition to this, his manipulation of auras enhances physical attributes so that Orochimaru's strategies and techniques would pale in comparison. The power and battle insight Meruem possesses would make him practically unstoppable, wielding the ability to effortlessly defeat Orochimaru from Naruto.
6) Madara Uchiha (Naruto Shippuden)

Madara Uchiha is one of the most powerful shinobi in Naruto Shippuden, who can defeat Orochimaru since he possesses great strength and god-like abilities as the Jinchuriki of the Ten-Tails. Madara has the near-limitless chakra, enhancement of the physical body, and even world-manipulating powers.
His Rinnegan entitles him to elementary catastrophes, such as the Limbo clones, which exist in some invisible dimension, thus making them undetectable and deadly. Besides this, his mastery of the Susanoo, a giant warrior almost indestructible, enables Madara to fight any opponent with almost no effort.
7) Meliodas (The Seven Deadly Sins)

The Dragon's Sin of Wrath from The Seven Deadly Sins, Meliodas has an enormous amount of power that would overpower Orochimaru in an instant. His ability, Full Counter, reflects magic at double the force against the attacker; therefore, no offensive attack is effective against the Sin of Wrath.
Meliodas also possesses demonic powers that give him superhuman strength, speed, and regeneration capable of rivaling even the most formidable opponents. His demon form would let him do several different destructive energy-based attacks like Trillion Dark. He is sure to blow Orochimaru away without much effort.
8) Roronoa Zoro (One Piece)

The master swordsman of One Piece, Roronoa Zoro, is incredibly strong with great speed and exceptional swordsmanship. He can use three swords at once with great techniques such as "Asura," which gives him the upper hand in battle.
Pure endurance and willpower can get Zoro through almost anything, and adding observation and armament Haki onto that makes the additional layers of protection and power nearly too much to handle. With his destructive sword technique and intense fighting spirit, Zoro can easily cut Orochimaru down.
9) Alucard (Hellsing)

Alucard from the Hellsing series is the ultimate vampire, who is almost immortal with regenerative powers that can recover from any injury. His crushing force, rapid speed, and wide array of supernatural powers make him a terrifying opponent.
He can summon an army of souls he has consumed and master dark magic that may overwhelm any opponent with ease. Resilience alone, with the assault that would not stop, overpowered Orochimaru, Alucard is a power that could take him down without much effort.
10) Giorno Giovanna (JoJo's Bizarre Adventure)

Giorno Giovanna is the main character in the anime JoJo's Bizarre Adventure: Golden Wind, who fights with his Stand, Gold Experience Requiem. This powerful Stand can revert any action or attack to zero, rendering all efforts against Giorno completely futile.
Whatever Orochimaru tries, Giorno can revert at will in no time without a fuss, sending him into an endless loop wherein he cannot fulfill his goals. Reality Reset by Gold Experience Requiem makes Giorno untouchable, one of those who would make a child play with Orochimaru.
Final thoughts
While Orochimaru is among the more cunning and powerful villains in the series of Naruto, he is far from being invincible within the broader anime world. Characters on this list range in their abilities that easily outrank Orochimaru in talent, each with overwhelming power, unique abilities, or strategic genius that Orochimaru simply cannot keep up with.
From Saitama, Gojo, and Alucard's pure and simple brute strength to Giorno Giovanna's reality-bending Stand, these anime characters would dispatch Orochimaru without much trouble at all, nullifying all of his plans and aspirations.
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