The Apothecary Diaries chapter 80 will be released on Friday, April 25, 2025, at 12 am JST. Like the previous chapters, chapter 80 will be available on Manga Up!, the official app of Square Enix magazine.
The previous episode showcased the first encounter between Maomao and Shenmei as the female protagonist learned about the latter's influence on the people. On the other hand, Maomao continued her synthesis of an 'eternal youth drug,' but Chou-u tried saving her, complicating things to the next level. Eventually, Maomao was sent to the Pit due to her rude behavior.
Disclaimer: The article contains spoilers for The Apothecary Diaries.
The Apothecary Diaries chapter 80 release date and time

The Apothecary Diaries chapter 80 is set to be released on April 25, 2025, at 12 am Japan Standard Time. The release date and time of the upcoming chapter will vary according to different time zones:
Where to read The Apothecary Diaries chapter 80?

Square Enix's Manga Up! website is the only official way for international fans to access The Apothecary Diaries chapter 80. The manga service is available for fans worldwide and they can access the platform through its website and official app. New chapters are released in different fragments.
The first few chapters of the series are free and new chapters require 'XP' points.
Japanese fans can read the chapter through the official magazine release, Monthly Big Gangan, of The Apothecary Diaries. Moreover, local fans can also read the chapter on Square Enix's Japanese web platform, Gangan Online.
The Apothecary Diaries chapter 79 recap

The Apothecary Diaries chapter 79, titled The Pit, commenced with a focus on Maomao as she visited Lady Shenmei, the mother of Consort Loulan. Behind the Lady were people indulging in pleasure, which had Maomao questioning the vapors present inside the room. After having a brief conversation with Lady Shenmei, Maomao returned to her room.
The chapter then revealed Lady Shenmei's ruthless side as she used her heritage to berate others. Moreover, as a former consort, Shenmei was extremely jealous of beautiful people who had her appointing apothecaries who would design a drug to restore the Lady's youth. Unfortunately, Maomao was kidnapped for the same reason.

However, Maomao had no leads because she knew there was nothing like an 'eternal youth drug.' As she looked into the previous apothecaries' notes for clues, Maomao stumbled across a note from Chou-u that asked her to flee. He also sent a wire alongside the note, hinting that he might be aware that Maomao was being held against her will.
Ironically, before Maomao could act, Chou-u was caught by his lady-in-waiting. After gathering everyone, it was decided that the guard was responsible for Chou-u's actions. Moreover, Lady Shenmei also arrived on the scene and threatened the boy and his guard. Maomao couldn't hold her hatred against Shenmei and called the latter a 'twisted old hag.'
As expected, Shenmei started hitting Maomao on this remark and ordered her servant to take the female protagonist to the water prison. However, Suirei interrupted her mother's talk and Shenmei took all her anger out on her daughter. Eventually, on the recommendation of Loulan, Maomao was instead sent to the Pit.
With a creepy smirk, Shenmei agreed to her other daughter's recommendation as Maomao was sent to the Pit. Accompanied by some of Shenmei's servants, Maomao entered a room that kept going downwards into the ground. Eventually, Maomao was left behind in a space with some snakes. However, Maomao got excited, instead of getting scared, by the snakes.
What to Expect from The Apothecary Diaries chapter 80? (Speculative)

The Apothecary Diaries chapter 80 is titled Feifa. As hinted by the climax of the previous episode, the next installment might see a showdown between the snakes and Maomao. As given by the female protagonist's excitement, the showdown might not go according to Shenmei's plans.
Moreover, as hinted by the title of this chapter, The Apothecary Diaries chapter 80 might see a closure on Feifa (a pistol) and how Shenmei's family mass-produced these weapons.
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