Top 10 biggest upsets in NBA history

#6 Memphis Grizzlies VS San Antonio Spurs (2010-2011)

Memphis Grizzlies defeat the favourites Spurs in six games

The famous combination of Tim Duncan, Manu Ginobili, Tony Parker and Greg Popovich went past everybody during the 2011 regular season, posting an outstanding record of 66 wins and 16 loses. Being seeded first overall, they faced the 8th seeded Memphis Grizzlies who had struggled all season long.

Grizzlies came out and won game 1 of the series and never looked back. They were younger, faster and more athletic, and the Spurs had no response for Zack Randolph in the post. Zach Randolph (21.5 points per game in the series), Mike Conley (14.3 points per game) and Marc Gasol (14.2 points per game) led the way as the Grizzlies knocked off the Spurs in six games to become just the fourth 8-seed to topple a 1-seed since the playoffs expanded to 16 teams in 1984.

Even though the Grizzlies ended up losing in the next round, to a team that once featured Kevin Durant, Russell Westbrook, and James Harden, the Oklahoma City Thunder, the upset over the Spurs remains a signature moment in their franchise history which helped give birth to the grit and grind Grizzlies as we know them today.