Boston Celtics injury report (Dec. 4): Jayson Tatum and key starter uncertain to play vs Pistons 

The Boston Celtics host the Detroit Pistons on Wednesday night at the TD Garden. The Celtics are 17-4 this season and have won nine of their last 10 games heading into this contest. The defending NBA champions have dealt with a few injury issues amid this run, and that will continue to bug them.

However, that may not stop the Celtics from getting another win, especially against the Pistons, who have hit a slump lately, winning only two of their last eight games. Detroit is 9-14 entering this contest and playing on the second night of a back-to-back.

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Boston Celtics Injury Report: Jayson Tatum and Jrue Holiday iffy to play

The Boston Celtics could miss two starters, including MVP candidate Jayson Tatum and starting point guard Jrue Holiday, against the Detroit Pistons. According to the team's latest injury report, they have a questionable status.

Tatum is dealing with a right knee tendinopathy injury, and Holiday has the same ailment on his left knee. Anton Watson and JD Davison are the other two players on the injury report for the Celtics, ruled out, citing G League assignments.

Tatum hasn't missed a game this season, averaging 28.4 points, 8.6 rebounds, 5.6 assists and 1.3 steals in 21 games, leading the team in all categories. Meanwhile, it will be Holiday's third absence of the year if he doesn't suit up on Wednesday. In 19 outings, he has managed 11.7 ppg, 4.2 rpg and 3.9 apg. The Celtics are 2-0 in his absence.

Holiday also missed Monday's contest against the Heat. The Celtics won that, 108-89, behind Jaylen Brown's 29 points and Jayson Tatum's 18-point, 11-rebound double-double.

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Boston Celtics predicted starting lineup and depth chart vs. Detroit Pistons

The Boston Celtics could start Jrue Holiday, Derrick White, Jaylen Brown, Jayson Tatum and Kristaps Porzingis. If Holiday and Tatum are out, Sam Hauser and Al Horford could replace them in the starting lineup. Derrick White would primarily play as the point guard, while Jaylen Brown will be Boston's No. 1 option offensively.

Here's the Celtics' depth chart for this contest:

PG	Jrue Holiday*	Payton Pritchard	Jordan Walsh
SG	Derrick White	Sam Hauser
SF	Jaylen Brown	Jaden Springer	Drew Peterson
PF	Jayson Tatum*	Al Horford	Xavier Tillman
C	Kristaps Porzingis	Luke Kornet	Neemias Queta

The game will begin at 7:30 p.m. ET. NBC Sports Boston will cover the game locally, while fans outside the city can watch the contest live online via NBA League Pass.