Detroit Pistons vs New York Knicks Prediction and Betting Tips - April 21 | 2025 NBA Playoffs, Game 2

The Detroit Pistons will take on the New York Knicks in game two of the Eastern Conference’s first round. The Pistons lost game one 112-123 following a fourth quarter flurry from the New York Knicks.

The team will now go to Madison Square Garden on Monday to play their second game of the 2025 NBA playoffs. The Pistons haven’t won an NBA playoff game since 2008 and are desperate to end their drought. As such, expect Cade Cunningham and Co. to play for the win on Monday.

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Detroit Pistons vs New York Knicks Preview, Prediction, Starting Lineups and Betting Tips

The Pistons-Knicks game will take place at Madison Square Garden on Monday. The game is scheduled to tip off at 7:30 p.m. ET and can be broadcast live with NBA League Pass and FuboTV.

Moneyline: Pistons (+210) vs Knicks (-258)

Odds: Pistons (+6.5) vs. Knicks (-6.5)

Total (O/U): Pistons (o221 -110) vs. Knicks (u221 -110)

Editor's note: The odds could change closer to tipoff, as the odds listed were based on available information at the time of writing.

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Detroit Pistons vs New York Knicks Preview

Jalen Brunson, Karl-Anthony Towns, and OG Anunoby were key in the Knicks’ game one win over the Pistons. Brunson recorded a game-high 34 points and eight assists. Towns finished with 23 points, 11 rebounds, five assists and four steals. Lastly, Anunoby scored 23 points with seven rebounds, five steals and two blocks.

Meanwhile, the Pistons relied on Cade Cunningham, who finished his night with 21 points, 12 assists and six rebounds. Tobias Harris recorded a team-high 26 points. Malik Beasley was also key, scoring 20 points off the bench. Most of what the Pistons did on Saturday worked as they headed into the fourth quarter with an eight-point lead.

Unfortunately, the team fell apart in the fourth and was outscored by 19 points while committing six turnovers. Detroit will need to take better care of the ball and make their shots count during the final stretch if they hope to steal game two from New York.

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Detroit Pistons vs New York Knicks Predicted Starting Lineup

Pistons

PG: Cade Cunningham | SG: Tim Hardaway Jr. | SF: Ausar Thompson | PF: Tobias Harris | C: Jalen Duren

Knicks

PG: Jalen Brunson | SG: Mikal Bridges | SF: Josh Hart | PF: OG Anunoby | C: Karl-Anthony Towns

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Detroit Pistons vs New York Knicks Betting Tips

Cade Cunningham’s assist prop is set at 9.5 for Monday’s game against the Knicks. He dished out 12 assists in the first game and will be relied on to run Detroit’s offense for the rest of the series. Cunningham ended the regular season recording 9.1 assists per game.

Defenders will guard Cade more tightly during the playoffs, so he’ll move the ball around more often. As such, it would be better to bet on him to go over his assists prop on Monday

Karl-Anthony Towns’ rebounds prop for Monday is set at 11.5. Towns has been one of the best rebounders in the league this season, recording 12.8 per game. So, it could pay off to bet on KAT going over his rebounds prop on Monday.

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Detroit Pistons vs New York Knicks Prediction

The Detroit Pistons gave the New York Knicks a run for their money on Saturday. Unfortunately, the team didn’t have the legs to keep their performance levels up in the fourth and collapsed late. Unless the Pistons can figure out a way around that, expect the Knicks to win in what should be a tightly contested game.