Philadelphia 76ers vs Cleveland Cavaliers Prediction and Betting Tips | Dec. 21

The Philadelphia 76ers visit the Cleveland Cavaliers on Saturday night as part of the NBA's busy 12-game slate. It will be the second matchup of the season between the teams, with the Cavaliers beating the Sixers 114-106 in Philly on Nov. 13.

The Sixers have been playing better recently, with six wins in their last 10 games. They can't seem to escape the injury bug, although their three All-Stars – Joel Embiid, Paul George and Tyrese Maxey – played together in their previous game against the Charlotte Hornets.

Meanwhile, the Cavaliers remain atop the standings with the best record in the NBA at 24-4. They are on a three-game winning streak and have won seven of their last 10. They dominated the Milwaukee Bucks on Friday to send a message to the rest of the league.

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Philadelphia 76ers vs Cleveland Cavaliers Game Details and Odds

The 76ers-Cavaliers game is scheduled to take place at Rocket Mortgage FieldHouse in Cleveland, Ohio at 8:00 p.m. ET. It will be televised locally on NBC Sports Philadelphia Plus and FanDuel Sports Network Ohio.

Fans can also watch it via live stream on NBA League Pass and FuboTV, which are paid subscriptions.

Moneyline: 76ers (+405) vs. Cavaliers (-550)

Spread: 76ers +11 (-110) vs. Cavaliers -11 (-110)

Total (O/U): 76ers o219.5 (-115) vs. Cavaliers u219.5 (-111)

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Philadelphia 76ers vs Cleveland Cavaliers Betting Tips

Tyrese Maxey has an over/under of 24.5 points for Saturday's game. Maxey is averaging 24.9 points per game this season and is favored to go over. With Joel Embiid sitting the second game of a back-to-back, don't overthink and bet on Maxey to score at least 25 points.

Paul George had five points in the Philadelphia 76ers previous game against the Charlotte Hornets. George is favored to go over 20.5 points, which is higher than his season average of 16.3 ppg. He has not gone over 20.5 points in three of his last four games, so bet on the under.

Donovan Mitchell is averaging 23.5 ppg this season and is favored to score not more than 23 points. Mitchell has scored at least 24 points just once in his last five games. He doesn't need to score a lot of points, so listen to the odds and bet on Mitchell to go under 23.5 points.

Darius Garland is favored to go over 19.5 points and is averaging 20.1 ppg this season. Garland has reached 20 points or more twice in his last five games. Place your money on him to go under 19.5 points for the potential for a better payout.

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Philadelphia 76ers vs Cleveland Cavaliers Prediction

It's not surprising that the Cleveland Cavaliers are favored to beat the Philadelphia 76ers. Joel Embiid is not expected to play since it's the second game of a back-to-back. It puts the Cavs in the driver's seat, although the Sixers have shown some heart recently.

The prediction is a win for Cleveland, with the Sixers covering the spread and the total going over 219.5 points.