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The Duke Blue Devils go on the road to play the Louisville Cardinals on Saturday, Oct. 28 at 3:30 p.m. ET.
Duke suffered a 38-20 loss to the Florida State Seminoles on Saturday, as the Blue Devils are now 1-3 in their last four. Louisville, meanwhile, was upset by Pittsburgh 38-21 two weeks ago as they had their open week on October 21.
Duke vs. Louisville: Match Details
Fixture: Duke Blue Devils (5-2) vs. Louisville Cardinals (6-1)
Date & Time: Saturday, Oct. 28 at 3:30 p.m. ET
Venue: L&N Federal Credit Union Station
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Duke vs. Louisville: Betting Odds
Spread
Duke +4 (-110)
Louisville -4 (-110)
Moneyline
Duke +160
Louisville -192
Total
Over 46 (-110)
Under 46 (-110)
Duke vs. Louisville Picks
The Duke Blue Devils got Riley Leonard back last week, but he struggled against FSU and did leave the game, but he is listed as day-to-day. If he does play, expect Leonard to be much better as he has a full game under his belt, as well as going up against a Cardinals defense that struggled two weeks ago. Take Leonard's over passing yards, as the line is lower after a bad game last week.
Jack Plummer, meanwhile, has been turning the ball over too often, so take the Louisville Cardinals quarterback to throw an interception in this game. In his last five games, Plummer has thrown five interceptions and goes against a Duke defense that has recorded an interception in each of their previous two games.
Duke vs. Louisville head-to-head
Duke and Louisville are set for just their fourth meeting ever. The Cardinals are a perfect 3-0 against the Blue Devils, with Louisville winning each game by ten or more points.
Duke vs. Louisville prediction
Louisville suffered a stunning loss to Pittsburgh and has since had to sit on it for a week. Riley Leonard struggled last week but should be more comfortable and in rhythm in this game in what should be a fairly high-scoring game.
Louisville should come out with a ton of motivation after their first loss of the season and get out to an early lead. It will be a back-and-forth game but one the Cardinals edge out.
Prediction: Louisville wins the game by a field goal as the Cardinals don't cover the spread.
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