Louisville vs. Notre Dame prediction & betting tips - September 28 | College Football Week 5

We have an exciting game between nonconference-ranked foes as the 15th-ranked Louisville Cardinals battle the 16th-ranked Notre Dame Fighting Irish on Saturday. These teams have both gotten off on the right foot this season and are looking to continue that here.

The Cardinals (3-0) are looking to remain undefeated. They are coming off a 31-19 home victory over the Georgia Tech Yellow Jackets on Saturday. Senior quarterback Tyler Shough had a good showing as he finished 13-of-19 for 269 yards with a pair of touchdown passes, adding four rushing attempts for 19 yards (4.8 yards per carry).

The Fighting Irish (3-1) are currently on a two-game winning streak after a 28-3 home win over the Miami RedHawks. Senior quarterback Riley Leonard had his best game with the program, going 16-of-25 for 154 yards and a touchdown.

Louisville vs. Notre Dame: Prediction

The Louisville Cardinals have been able to cover the spread well this season (3 times) and should continue to do so. Riley Leonard has looked shaky under center this season and the Cardinals can apply pressure and force errors.

Tyler Shough has thrown for multiple touchdowns in each game this season and while the Fighting Irish defense is the best he has faced, Shough should do well. He is an experienced quarterback, playing in games during the 2019 season, and has shown the ability to get into the end zone consistently.

We are taking a bit of a flyer on running back Jeremiyah Love having 25+ receiving yards as well. He has not reached this total in a game this season but is averaging 1.5 receptions per game. With the Notre Dame offense needing a bit of a spark, do not be surprised to see a running back screen be called and get some yardage.

Louisville vs. Notre Dame: Betting tips

Tip 1: Louisville Cardinals +6.5 (-108)

Tip 2: Tyler Shough 2+ Passing Touchdowns (+120)

Tip 3: Jeremiyah Love 25+ Receiving Yards (+285)

Louisville vs. Notre Dame: Head-to-head

These two teams are not too familiar with one another as this is only the fifth time that they have played. The series is tied at two wins apiece and they played last season in Louisville, where the Cardinals secured a 33-20 home win.

How to watch Louisville vs. Notre Dame

The game between the Louisville Cardinals and the Notre Dame Fighting Irish is only going to be available to watch through streaming. The game is going to be streaming live on Peacock and is the only way to watch if you are not physically at Notre Dame Stadium.