Pitt vs. North Carolina Prediction & Betting Tips October 5 | College Football Week 6

The Pittsburgh Panthers will go on the road for an ACC matchup versus the North Carolina Tar Heels this weekend in Chapel Hill. North Carolina has gotten out to a modest start to their season, winning three of its first five games for a 3-2 record. Pitt, meanwhile, has looked impressive to start the season as the Panthers enter Week 6 with a 4-0 record in four games.

The Panthers are coming off a win in Week 5 after topping the Youngstown State Penguins last time out with a 73-17 win. Pitt's offense has looked like one of the top units in the ACC through four games, as the Panthers average 48.5 points and 522 yards of total offense per game. Pitt has defeated Kent State, Cincinnati, West Virginia and Youngstown State on the way to its 4-0 record.

On the other hand, the Tar Heels are coming off an upset loss to Duke in Chapel Hill in Week 5 and will look to bounce back following their second-straight loss. North Carolina was involved in a historic shoot-out in Week 4, suffering their first loss of the season at the hands of the James Madison Dukes in the 70-50 slugfest. North Carolina kicked their season off with a 3-0 record, topping Minnesota, Charlotte and NC Central in their first three games.

Here's an official prediction for this Week 6 matchup and some betting tips to boot.

Pitt vs. North Carolina: Prediction

This matchup is slated to be one of the most entertaining games of the entire Week 6 slate. With an over/under of 64.5, even Sportsbooks are anticipating a shootout this weekend. The Tar Heels open as a 2.5-point underdog this week, a mark that could be wider given Pitt's success so far this season.

Take the Panthers in this Week 6 ACC clash, by more than the 2.5 mark given to them. The Tar Heels will pose a threat to the Panthers, but Pitt should manage its fifth straight win to open the season.

Pitt vs. North Carolina: Betting Tips

Tip 1: Pitt Panthers -2.5 (-115)

Tip 2: Total Points Over 63.5 (-105)

Tip 3: Omarion Hampton Over 121.5 Rushing Yards (-118)

Pitt vs. North Carolina: Head-to-Head

Pittsburgh and North Carolina will meet for the 18th time this weekend. The Tar Heels have won each of their last two matchups and will look to build their win streak to three versus the Panthers. Pitt's last win in the series came in the 2021 season with a 30-23 overtime win.

The two schools first squared off back in 1974 and are a yearly matchup as ACC foes. The rivalry has been split 2-2 over the last four matchups.

Who do you think will come out on top in this Week 6 matchup? Let us know your thoughts in the comments section below.