Who is favored to win Ole Miss vs. South Carolina? Head-to-head records, odds and more

The No. 12 Ole Miss Rebels will face the South Carolina Gamecocks in a Week 6 meeting between one-loss SEC programs. Ole Miss began the year with four consecutive blowout victories over the FCS-level Furman Paladins, Middle Tennessee State Blue Raiders, Wake Forest Demon Deacons and Georgia Southern Eagles.

They were dominant on both sides in every matchup, as their lowest margin of victory was 34. The Rebels' average margin of victory was 49.5 points per game, outscoring their opponents 220-22. However, it was a different story in their Week 5 SEC opener as they suffered a 20-17 home loss to the Kentucky Wildcats following a go-ahead touchdown with 2:25 left.

South Carolina began the season by barely defeating the Old Dominion Monarchs. They were even more impressive the next week when they dominated the Kentucky Wildcats in their SEC debut. The Gamecocks' next meeting was in Death Valley when they nearly stunned the then-16th-ranked LSU Tigers.

The game was marred by controversy as many believed the officials wrongfully cost them the game in the final stages of the fourth quarter. South Carolina was able to bounce back in Week 4, beating Akron in a dominant performance. They had an open Week 5.

Who is favored to win Ole Miss vs. South Carolina?

The Ole Miss Rebels are favorites to beat the South Carolina Gamecocks, as they have -315 odds of improving to 5-1. The visitors have +250 odds of pulling off the upset and likely entering the Top 25 after being among the others receiving votes in the latest rendition of the AP Poll.

Take a look at the full odds for Saturday's Week 6 matchup below:

Team	Spread	Over/Under	Money Line
Ole Miss Rebels	-9.5 (-105)	Over 53.5 (-110)	-315
South Carolina Gamecocks	+9.5 (-115)	Under 53.5 (-110)	+250

Ole Miss vs. South Carolina head-to-head

The Ole Miss Rebels and South Carolina Gamecocks are set to meet for the 18th time. The two teams first met in 1947, with the Rebels winning in a dominant 33-0 shutout. They also hold a narrow series lead as they are 9-8 against their SEC rivals.

They have not met since 2020. The Rebels hold the longest winning streak in the matchup, as they won five consecutive games between 1981 and 2004.