Ohio State vs Iowa Prediction & Betting Tips - October 5th | College Football Week 6

Ohio State vs Iowa is set to take place on Saturday, October 5th, at 3:30 p.m. The game should be a stiff test for the Hawkeyes (3-1) as they face No. 3 Ohio State (4-0). Their previous ranked matchup was against Iowa State in week 2.

The Ohio State Buckeyes are coming off a 38-7 victory over Michigan State. It was the team's fourth straight win to start the season. Iowa is coming off an open week, but before that, they had won two games in a row. Most recently, the Iowa Hawkeyes won 31-14 over Minnesota in week 4.

Ohio State vs Iowa prediction

Looking at Ohio State to start the season, it is hard to find a weakness. The team has performed exceptionally well on both offense and defense. In four games, the worst defensive performance the Buckeyes had was giving up 14 points against Marshall in week 4. They have given up 13 total points in its other three games combined.

Additionally, the team has done a good job generating offense, starting the season with a 52-point performance against Akron. The Buckeyes followed that up by putting up 56 points in a shutout win over Western Michigan and had 49 and 38 points in each of its last two games against Marshall and Michigan State.

However, the one thing to consider with Ohio State is that the team has not been tested yet. Not only has the team not faced a ranked opponent, but it has not faced a team that is anywhere close to its quality. The Buckeyes have been beating up on lesser opponents, so it is hard to gauge exactly how strong a team they are.

On the other hand, the Hawkeyes started the year with a 40-0 win over Illinois State. Next came a 20-19 in-state loss to rival and No. 16 Iowa State. Iowa bounced back, winning 38-21 over Troy and 31-14 over Minnesota.

Ultimately, this should not be a close game; the odds reflect that. Ohio State is a -1494 favorite to win this game, and Iowa is a +855 underdog. So, a comfortable victory is on the cards for the Buckeyes.

Ohio State vs Iowa betting tips

Tip #1: Avoid betting on the moneyline. Iowa is too much of an underdog to bet on, and the reward for betting on Ohio State is not high enough.

Tip #2: Wager on Ohio State to cover the 19.5 point spread (-110).

Tip #3: Bet over on the 45.5 point total (-110).

Ohio State vs Iowa head-to-head

Ohio State and Iowa will face off for the 20th time this weekend in Week 6 of the college football season. The previous 19 games were played between 1989 and 2022, and the Buckeyes enjoy a significant advantage in the meeting, having gone 16-3. Iowa last won in 2017, with a 55-24 win over Ohio State.