Ohio State vs Northwestern prediction & betting tips - Nov. 16 | College Football Week 12

The No. 2-ranked Ohio State Buckeyes are on the road to face the Northwestern Wildcats on Saturday at noon ET. The game can be seen on the Big Ten Network.

Ohio State (8-1, 5-1 Big Ten) won 45-0 over Purdue on Saturday. Northwestern (4-5, 2-4) is coming off an open week and won 26-20 in overtime against Purdue in Week 10.

Ohio State vs Purdue: Preview

The Buckeyes are 29-point road favorites and the over/under is set at 44.5 points.

Ohio State is on a three-game winning streak. It was a dominant performance against the Boilermakers, as they carried the momentum after a big win over Penn State on Nov. 3.

"Good to see us respond coming off an emotional win. You watch it all across college football," Buckeyes coach Ryan Day said on Saturday, via 247Sports. "We've been a part of that, too, where you come off an emotional win like that and you have to let that go. We're in November now. Every single snap matters. Every play matters.

"And that being said, I think some guys took that opportunity in the second half, some young players, to use those snaps as an opportunity to make a name for themselves. Because we're going to need depth as we continue to go through November. We've already seen that. So good to see us respond coming off an emotional win last week."

Ohio State is led by Will Howard who has thrown for 2,237 yards, 22 touchdowns, and five interceptions. Quinshon Judkins has 647 rushing yards and six TDs, while Jeremiah Smith has 765 receiving yards and nine TDs.

Defensively, the Buckeyes are led by Denzel Burke and Davison Igbinosun's two interceptions, JT Tuimoloau's five sacks and Sonny Styles' 57 tackles.

Meanwhile, Northwestern has a tough road ahead to make a bowl game. It has to beat two of Ohio State, Michigan and Illinois to be bowl-eligible.

The Wildcats are led by Jack Lausch who has thrown for 1,120 yards, five TDs and four interceptions. Cam Porter has 387 rushing yards and A.J. Henning has 426 receiving yards for three TDs.

Defensively, Theran Johnson has two interceptions, Aidan Hubbard has four sacks and Mac Uihlein has 58 tackles.

Ohio State should win this matchup ahead of a pivotal game against Indiana in Week 13. The Buckeyes need to beat the Hoosiers to have a chance to play in the Big Ten championship game.

Prediction: Ohio State 35, Northwestern 10

Ohio State vs Northwestern: Betting Tips

Tip 1: Northwestern +29 (-110)

Tip 2: Over 44.5 points (-108)

Tip 3: Quinshon Judkins anytime TD scorer