USC vs. Oregon prediction, odds, and picks - November 11 | NCAAF Season 2023

The USC Trojans are in Oregon to play the Ducks on Saturday at 10:30 p.m. ET.

Unranked USC (7-3, 5-2 Pac-12) is coming off a 52-42 loss to the Washington Huskies and is 1-3 in its last four games. No. 6 Oregon (8-1, 5-1), meanwhile, is coming off a 63-19 blowout win over Cal last weekend.

USC vs. Oregon: Game details

Matchup: USC Trojans (7-3) vs. Oregon Ducks (8-1)

Date & Time: Saturday at 10:30 p.m. ET

Venue: Autzen Stadium

USC vs. Oregon: Betting odds

Spread

USC +15.5 (-110)

Oregon -15.5 (-110)

Moneyline

USC +625

Oregon -950

Total

Over 73.5 (-112)

Under 73.5 (-108)

USC vs. Oregon: Picks

The USC Trojans have been figured out this season, as they have a high-powered offense, but their defense is one of the worst in college football. In this spot, I like Caleb Williams to throw over 1.5 passing touchdowns.

Williams has gone over 1.5 passing touchdowns in each of USC's last two games, and he'll be motivated to continue to dominate this season and go into the NFL on a high.

The Oregon Ducks, meanwhile, look like a legit national title contender but will need to win the Pac-12 if they are going to win it all. Oregon is led by Bo Nix, who should throw for a ton, but I like the over for rushing yards for Mar'Keise Irving. Irving is averaging 107 rushing yards per game over the last four.

USC vs. Oregon: Head-to-head

USC and Oregon have played each other 62 times since 1915. Overall, the Trojans lead the all-time series 38-22-2.

USC vs. Oregon: Prediction

The USC Trojans fired their defensive coordinator this week as their defense has been one of the worst in college football. Oregon, meanwhile, comes in with one of the best offenses in the country and a solid defense.

Although limiting Caleb Williams will be tough, the Ducks should be able to slow him down enough to cruise to a blowout victory here. Nix and the Ducks offense will score on nearly every possession and cover the spread.

Prediction: Oregon blows out USC