Yes, Resident Evil 8 is connected to Resident 4 in many aspects which includes ambience and gameplay mechanics.
Following a handful of remakes, Capcom has finally released Resident Evil Village, the eighth main entry in the Resident Evil franchise. Resident Evil Village continues in the footsteps of Ethan Winters but switches the setting to Eastern Europe.
Yet, Resident Evil Village is linked to more than only biohazard; the game has several subtle allusions and clear linkages to the rest of the Resident Evil franchise.
Does Resident Evil 8 have any link to other iterations in the franchise?
Resident Evil Village links to the rest of the franchise by continuing and explaining the Resident Evil 7 biohazard. Resident Evil Village, however, includes several subtle connections to the rest of the franchise. Some of these connections, such as the identity of The Duke and the BSAA bioweapons discovered by Chris and his crew, may have broader significance for future incarnations.
Are Resident Evil 4 and 8 connected?
While the ambiance and location of Resident Evil 8 are comparable to that of Resident Evil 4 (RE4), we have a more intimate connection with The Duke. The Duke signals the reintroduction of a Merchant system akin to the Merchant in RE4. But there's more to it than that. If you listen to The Duke's background conversation, you'll hear him say the famous remark, "What're ya buying?"
Despite its seeming innocence, this is the Merchant's catchphrase in RE4. To further link the two Merchants, The Duke continues this statement by stating that it was something an old buddy used to say.
What is Resident Evil 8 about?
Resident Evil 8 is about Oswell Spencer, who started this franchise. By the end of Resident Evil 8, players come upon a chamber containing Mother Miranda's writings. Miranda and Spencer's correspondence is one example of this type of writing.
We learn from this message that Spencer was Miranda's pupil and visited her community 15 years ago. He mentions discovering the progenitor virus in Africa and launching Umbrella, which kicks off the Resident Evil events. Miranda's teachings influenced Spencer.