#2 No more Zapping System (Separate campaign for Leon and Claire)
For better or worse, the upcoming RE 2 remake won't feature the original's Zapping System where you could swap between characters in the B playthrough of the game.
According to Capcom, this made the game very tedious and involved a lot of backtracking so they decided against it.
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Instead, we get two separate campaigns for Leon and Claire which will both play differently and not inter-dependent as previously.
Though that doesn't mean that Leon and Claire won't interact midway in the game.
All the story encounters are still there thankfully.
#3 More Depth in the narrative
Even though the main basic storyline remains the same. Cacpom has re-designed a lot of story elements, especially regarding the interactions with different NPCs in the game.
Characters who had fewer dialogues, or less screen time in the original game may have extra content, some extra detailing and interactions this time around.
Capcom has confirmed that all the characters from the original are returning and there's a major possibility of seeing some new faces as well in this terrifying depiction of a 20-year-old game.
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