#2 Losing the ball in midfield
Mauricio Pochettino's Spurs side are a very accomplished pressing team. In a big game like this, pressing and harrying the opposition into mistakes will be a vital part of the game plan for Spurs.
Manchester United have been dispossessed a whopping 236 times this season. Their central midfielders, Paul Pogba, Ander Herrera and Nemanja Matic have combined to lose the ball 75 times already.
Paul Pogba alone has lost it 45 times and that is more than any other central midfielder in the league has. The French international must understand that simplicity is genius in certain areas of the pitch especially in a game as vital as this.
Losing the ball in the midfield against Spurs will be catastrophic because it will unleash the Tottenham attack against Manchester United's fragile defense. With the quality and form that Spurs are in right now, it could leave United with too much to do at the end.