#3 Building from the back was the main issue

Manager Di Francesco's abandoning of the traditional 4-3-3 in favour of 4-5-1 did work up to a certain extent as Roma, as aforementioned, shut out Barcelona for a good 38 minutes before the opener. The likes of Messi and Suarez were forced to drop deep to pick up the ball while the visitors did well to contain him.
But the problem while negating Barcelona was that Roma couldn't counter press as the backline failed to push things forward. All they appeared to do was stay strong when the men in blue bombed forward but with no reactionary measures in mind. This helped Suarez and co. to build more pressure.
Take the first goal for instance. Bruno Peres albeit did well to fight the ball back from Alba, he lacked the pace while driving forward and ended passing it sideways while Dzeko stood completely unmarked just a few yards in front of him and could've launched a counterattack if serviced. But instead, that one indecision came back to bite Roma as Barcelona quickly recouped the ball and forced an own goal.
The capital outfit can still do some damage in the return leg at home, provided this folly is worked upon.