#1 Inclusion of Nelson Semedo
The fact that Ernesto Valverde started Nelson Semedo on the right flank against Rayo Vallecano raised some worries as he did not take him off in the whole game despite having Sergi Roberto on the bench. This probably suggests that he is planning to use Roberto as a right back tomorrow, and this might terribly backfire.
Roberto is a genius while going forward and attacking, as he understands his teammates' positioning and makes smart runs into the box. But that leaves Rakitic and Pique with huge responsibilities to defend the empty spaces left by Roberto on the right flank.
Nelson Semedo had Memphis Depay in his pocket all the time in the first leg, as the Dutchman was given the least time on the ball out of all Lyon players. He looked frustrated and Semedo deserves complete credit to keep a player of his quality silent throughout the game, something Roberto might not be capable of doing.
As it is an away game for Lyon, they might probably look to play on counter-attacks, exploiting the huge spaces left behind by Barcelona's fullbacks. The idea to play Roberto is likely to backfire, and if Barca gets knocked out from this competition, Valverde's time is most likely over.
Of course, the coach knows better, but according to me, Nelson Semedo must start, as the Portuguese has proven himself to be a player who can participate in attack and also do his defensive duties consistently.