#3 Isco marginalized on the wings
When reverting to 4-3-3, Isco becomes the right winger replacing Gareth Bale, with the freedom to overload the left wing along with Marcelo prompting Ronaldo to become the second striker.
The Spaniard's magnificent abilities are perfectly suited for playing as an attacking midfielder, similar to the role he played in the historic 2016/2017 season. Shifting him to the wing kills the advantage Isco thrives on; having a 180° field view that is utilized effectively when he plays as the tip of the diamond in the famous 4-3-1-2.
Moreover, the Spanish trequartista doesn't have the necessary pace to burst away from his markers and create an opportunity to cross. This was seen against Gremio as he always looked for runners in behind to release them into space, or else he'd shield the ball and wait, thus killing the fast tempo Zidane demands from his players.