#1 Manchester United (H), 7 April

Who else? If Manchester United can't defeat their local rivals away from home, the title race is most definitely over. On top of that, they simply can't afford any further slip-ups in their remaining matches either.
Alexis Sanchez may give the Red Devils a much-needed boost for the rest of the season, but even if the Chilean instantly hits the ground running at his new club, they may have left themselves too much do.
Mourinho's men also have a bumpy road ahead of them, starting with their away trip to Wembley to face Tottenham on 31 January. A lot of things will need to come together for the title race to become a race again.
Should United's quest for the title fail, they only have themselves to blame for it. Consecutive draws to Leicester, Burnley and Southampton in December may already have been the final nails in the coffin.