#4 Argentina vs Chile
Argentina have a dominating head-to-head record against Chile, winning 61 of the pair's 91 previous meetings while drawing 22 times and losing just twice.
However, recent Copa history between the duo does not make for good readj g for La Albiceleste. Chile beat Argentina in the 2015-16 Copa America finals to win their first two titles at the tournament, as the 14-time winners' long international title drought continued with twin penalty shootout heartbreaks.
Argentina have beaten Chile 2-1 in the group stage at both the last two editions of the Copa (2019 and 2016), but would look to finally land a first international title after a two-and-a-half decade hiatus.
The 2015-16 Copa finalists will open the action at the 2020 edition of the competition next summer. Lionel Messi will probably have his last chance of landing an international title at the 2020 Copa. The record goalscorer for Barcelona would look to improve on his rather pedestrian record of only 9 goals in 27 games in the tournament, and inspire his nation to a record-equaling 15th title at home.
#3 Brazil vs Ecuador
Continental heavyweights and 9-time winners Brazil have dominated their head-to-head rivalry against Ecuador, winning 26 of the pair's 32 meetings, drawing 4 times and losing just twice.
However, any thoughts of complacency must be warded off as their 2 defeats against Ecuador have come in competitive meetings (2002 and 2006 FIFA World Cup qualifying).
Brazil have since won 7 of their 9 meetings (all competitive fixtures except one), and they would look forward to retaining their 2019 title at the home of their arch-rivals Argentina next summer.