#2 FC Barcelona vs Real Madrid - November 2010
This is a game which the mere mention of it can ruin a Madridista's day. FC Barcelona hammered five past Real Madrid in the first El Clasico of 2010, which still remains one of the biggest margins ever recorded.
Los Blancos were utterly humiliated and to make matters worse, Ramos received an early call to the showers, courtesy of two obvious bookable offences.
Playing at right-back on the day, Sergio Ramos had one of the worst games of his life as David Villa proved to be deadly against Los Blancos and made a mockery of Ramos on more than one instance. Ramos took Villa down for his first booking and then slammed into Lionel Messi for his second cynical challenge of the night.
That foul caused a full-blown brawl on the field with Sergio Ramos pushing his international teammate, Carles Puyol to the ground. The referee then showed Ramos his second yellow and the right-back's contribution was done for the night. The damage was done for Ramos and Real Madrid as FC Barcelona went on to win the game, and win the league by four points that season.