#3 Chelsea's shaky defence
Talking about an atmosphere affecting the visiting team, Chelsea's already ailing defence could struggle even more at Old Trafford. The defending champions have put in a feeble fight to defend their title, although Manchester City's brilliance has something to do with that.
The biggest setback for Antonio Conte's side has been how unreliable the team's defence has been.
David Luiz has been suffering from a knee injury since October and rumours of a bust-up with the manager look to have cost him a first-team spot.
His replacement, 21-year old Andreas Christensen, has been consistently solid with Conte predicting him to be the club's future captain.
However, even the Dane has not been error-free as his misplaced pass gifted Lionel Messi and Barcelona a valuable away goal in the first leg tie of the Champions League round of 16.
Gary Cahill is no longer the dominant force he used to be, and Antonio Rudiger is yet to become a starter under Conte.
Only Cesar Azpilicueta has been reliable but he is not the tallest either. Thus, the backline has been struggling for a while now with thumping defeats at the hands of Bournemouth and Watford tell-tale signs.
Hence, United will be facing a Blues defence whose confidence is low; this will serve as fuel to motivate the Red Devils' attackers to deliver.