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#3 AS Roma
Ghana, Guinea and The Gambia have turned to AS Roma for their AFCON squads in this year's edition of the competition. AS Roma will be without the trio of Felix Afena-Gyan, Amadou Diawara and Ebrima Darboe after they were called up for AFCON by their respective countries.
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Jose Mourinho's men are in sixth place in Serie A, just six points outside the Champions League places. Teenage striker Afena-Gyan has scored two goals in five appearances for Roma, defensive midfielder Diawara has made eight appearances and Darboe has made five appearances in all competitions.
There are reports that Afena-Gyan is set to remain in Rome rather than join up with the rest of the Ghana squad for the tournament.
AS Roma will face Juventus, Cagliari, Lecce, Empoli and Genoa in a tricky run of fixtures in Serie A and the Coppa Italia for the duration of AFCON.
#2 AC Milan
Serie A title contenders AC Milan will have to do without three of their key players for the duration of AFCON. The trio of Franck Kessie, Ismael Bennacer and Fode Ballo-Toure have been called up by their national teams for the AFCON tournament.
Kessie has made 21 appearances for the Rossoneri this season, scoring five goals and providing one assist in all competitions. He will join up with the Ivory Coast squad for the tournament.
Meanwhile, Bennacer will join up with Algeria for the tournament. The defensive midfielder has made 24 appearances, contributing one goal and one assist. Ballo-Toure has been called up by Senegal. The left-back has made 11 appearances for AC Milan this season.
Currently trailing neighbors Inter Milan by four points, AC Milan have a huge month ahead of them with matches against Genoa, Venezia, Spezia, Juventus and Inter Milan.
#1 Napoli
Napoli will be the most affected side in Italy by AFCON. They will lose up to four regulars during the course of the tournament, including their top scorer Victor Osimhen. The Partenopei will be without Kalidou Koulibaly, Andre Frank Zambo-Anguissa and Adam Ounas, as well.
After an impressive start to the season, injuries have derailed Napoli's title charge and they are in third place in Serie A, seven points off the pace. Osimhen has made 14 appearances this season, with nine goals and two assists to show for his efforts. Koulibaly and Zambo-Anguissa have made 19 appearances each, while Ounas has marked his 14 appearances with two goals.
Napoli will face Sampdoria, Fiorentina, Bologna, Salernitana and Venezia during the course of AFCON, with their title ambitions set to be strongly tested.
