#1 Unbalanced team selection
You can't entirely blame the team for how they played. If a performance is so bad that you don't have a chance of beating a team that sits below you in the table, then the manager has to answer for his selection too.
While United's line-up certainly had the star power, the players didn't complement each other at all. Admittedly, you should try to make your opponents' play your game rather than the other way round. But when you face a multi-pronged attack like Tottenham's, you need defensive-minded players on the pitch.
Matic was terrible, but that is also down to the lack of support he had in the middle of the park. Pogba couldn't link-up with the attackers because he was attacked as soon as he touched the ball and the gap between him and his teammates was too large.
Lukaku, once again, appeared completely isolated up front, while Sanchez still needs to find his role in United's system.
The Red Devils lacked any form of balance in their line-up and the relentless pressure by Spurs ensured that they wouldn't find the time on the pitch to fix their broken system. While the players were completely outplayed by their opponents, Mourinho was equally outmanaged by Pochettino.