4) Lionel Messi vs Arsenal
Back when Arsenal regularly went beyond the Round of 16 in the Champions League, they still came up against the big guns in Europe and 2010 was no different. Pep Guardiola’s Barcelona had almost come away from the Emirates with a 2-0 win in the first leg before a late comeback saw the tie end 2-2.
At the Camp Nou, it was the Gunners who drew first blood through Nicklas Bendtner and suddenly Barcelona were on the ropes. 3-2 down on aggregate and suddenly Arsene Wenger’s side had a chance.
It lasted less than three minutes as the storm clouds quickly engulfed any ray of hope and Lionel Messi ran riot. As if a first-half hat-trick was not enough, he would humiliate the defence and poor Manuel Almunia with a fourth that stamped his authority on the game.