Right-Back: Ainsley Maitland-Niles
Replacing Hector Bellerin in the right back position on Sunday, Maitland-Niles played well in an unfamiliar position.
Perhaps, the biggest mistake he made in the game is giving away a soft penalty when he showed hesitation in his decision.
The Englishman is one of the brightest talents among the Arsenal youths and Wenger has shown clearly that he cherishes him.
Instead of naming Calum Chambers in the starting XI at the right-back position, it shows the manager's trust in him.
After his impressive performance and partnership with the defence, Maitland-Niles could be given the chance to shine if Bellerin were to remain unfit.
Centre-back: Calum Chambers
With Shkodran Mustafi possibly missing out due to a suspected groin injury, Chambers, who appeared as a substitute in the match against Watford, should be starring against the Italian giants.
A calm and fine display from him in the match in Italy was something he has provided in most of his games thus far, showing that he has benefited from his loan spell at Middlesbrough.
Centre-back: Laurent Koscielny
The Frenchman had been given a break ahead of the clash against Milan.
As Arsenal start to see themselves regaining the much-needed confidence in their games, it is time for Koscielny to step up and lead his team to a crucial victory.
His ability to read the game and get his team to move forward will be much appreciated in this upcoming tough fixture.
Feisty challenges are likely to come in as the visitors will attempt to give their best shot against the Gunners.
As such, the backline will be reliant on Koscielny's awareness and positioning throughout the game.
Left-back: Sead Kolasinac
The fit and muscular defender has found himself getting more time to play on the pitch following injuries to the first choice left-back Nacho Monreal.
Kolasinac had a couple of impressive showings in recent matches and it is unlikely that Wenger will risk Monreal by allowing him to play.