Midfielders
Fred
The Brazilian finally returned to the starting lineup against the Wolves after Nemanja Matic was red carded. He did not disappoint when compared to earlier in the season and also chipped in with a goal, his first for United. He was also getting into dangerous positions and tested Rui Patricio from a wonderfully taken free-kick.
With Matic still out due to suspension, Fred is likely to get the nod in a three-man midfield. His role will be to protect the back four and look to deliver penetrative passes through to the attacking players.
Scott McTominay
The towering youngster broke into the first team last season. However, his role this season has been limited as he has only come in as a substitute. This tie is a good chance for him to stake a claim for his place on the teamsheet.
Mourinho already had nice things to say about him. He will be mobile in this formation and could make the forward runs where possible. He will also be expected to do the dirty work in the middle of the pack when Derby County is on the counter-attack.
Andres Pereira
The Brazilian made a positive impact when he was brought on against the Wolves in the second half. He is technically gifted and can control the ball distribution from the midfield. If Paul Pogba is rested, then this would be the man Mourinho calls upon to slot into his position.
He has done little wrong to suggest that he should not start. Only a matter of outright competition for positions and tactical reasons have kept him out of the starting 11. He is also somewhat of a dead ball specialist.