#3 Thiago Silva (Chelsea) vs Alexandre Lacazette (Arsenal)
Thiago Silva has been a central part of Thomas Tuchel's plans at Chelsea, as the German tactician has played the Brazilian at the heart of defence. Silva has repaid his manager's trust, putting in some brilliant performances throughout the season.
Silva is expected to go up against Arsenal's Alexandre Lacazette, who is likely to play centre-forward for Arsenal on Wednesday. The Frenchman is Arsenal's top scorer this season, with 13 goals while also providing two assists.
Thiago Silva has largely been consistent for Chelsea, but it would be intriguing to see how he fares against Lacazette.
#4 Jorginho (Chelsea) vs Thomas Partey (Arsenal)
The Chelsea vs Arsenal game will see the midfield maestros of the two teams, Jorginho and Thomas Partey, lock horns in the middle of the pitch.
Jorginho has produced some steady performances since Tuchel has taken over, first in the company of Mateo Kovacic and then with N'Golo Kante. He has played the role of a metronome with relative ease, spreading the ball around the park with elan.
Meanwhile, Partey has acted as an all-action midfielder for Arteta, sweeping things at the back and progressing with the ball to initiate attacks for Arsenal. The game could be decided by how the two central midfielders fare on the day, making their duel a must-watch battle.
#5 Ben Chilwell (Chelsea) vs Calum Chambers (Arsenal)
Few expected Ben Chilwell to win back his place following Marcos Alonso's strong performances in the initial days of Thomas Tuchel's reign at Chelsea. However, Chilwell has bounced back in style, becoming an integral player for the German tactician.
Chilwell has shuttled down the left flank tirelessly for Chelsea this season. Against Arsenal on Wednesday, he could find Calum Chambers blocking his path on the wings. Chambers has turned his career around at Arsenal, establishing himself as the team's first-choice right-back this season.
However, Chambers will have to match the former Leicester City defender's energy, or it could be a long night for the Southampton academy graduate.