Left winger: Eden Hazard
Hazard has been the league's outstanding player this season, and he is arguably playing his best football since moving to London.
The Belgian is the top scorer in the league with seven strikes, and has three assists as well. Surprisingly, he has not taken the most shots, as eight others have taken more than his 23. He has completed the most dribbles with 22, and only five players have bettered his 17 key passes.
The United backline will have a tough task on their hands as they hope to contend the recently crowned Player of the Month.
Striker: Romelu Lukaku
Neither one of Chelsea's strikers have impressed, and Lukaku has consistently performed despite his team's struggles.
Mourinho has always been able to count on the Belgian's hold up play, work rate, and the constant running in behind defences. He has scored four goals for United thus far, and has been one of the better performers as many of his teammates have come under the microscope.
Right winger: Pedro Rodriguez
None of Alexis Sanchez, Willian, and Marcus Rashford have impressed considerably, so Pedro sneaks into the team.
The former Barcelona man has started just four league games this season, but he has three goals nonetheless. He had suffered an injury last month but he came off the bench against Southampton and is in contention to start against United.
Remember what happened two years ago when Pedro set the tone for an emphatic Chelsea victory? De Gea and company will surely keep a keener eye on him this time.