Right-back: Mauricio Isla (Chile)
An integral part of La Roja's consecutive triumphs in 2015 and 2016, Isla has only got better with age. In the current edition too, he already has an assist to his name off three key passes whilst also maintaining an average of 80% pass accuracy.
The 31-year old hasn't let his attacking instincts undermine his defensive responsibilities, blocking down the channels as well as making eight tackles so far. He also has fond memories of his last duel with the Uruguayans, having struck the winner in their 2015's quarter-final clash.
Centre-back: Diego Godin (Uruguay)
Atletico Madrid's departing skipper remains an indispensable figure at the heart of Uruguay's backline. Never to shy away from jumping into a tackle, he's won a staggering nine aerial duels so far - a testament to Godin's formidable aerial abilities, whilst also charging out of his line to get the ball ahead. He even registered an assist in the 4-0 drubbing of Ecuador in the opener.
Centre-back: Jose Gimenez (Uruguay)
Uruguay's man of the match in the hard-fought stalemate against Japan, Gimenez is the mortar to Godin's brick. With five aerial duels won alongside four tackles and clearances each, the Rojiblancos defender put on a defending masterclass to prevent the Samurais from causing further damage. Heck, he even netted the equaliser in the second half to salvage a point for the Blues. Alexis Sanchez and co. will have a massive fish to fry here.
Left-back: Jean Beausejour (Chile)
Thirty-five years of age and still going strong, Beausejour more than makes up for his lack of attacking instincts with sublime defensive performances. He currently averages two tackles per game in the competition and is also an excellent distributor of the ball. His experience would be worth its weight in gold against a potent Uruguay side.