Centre midfield: Ander Herrera (Manchester United)
The Spaniard has been colossal for the Red Devils this season and can be said as the second most important player for Jose Mourinho behind the obvious, Zlatan Ibrahimovic. Herrera has become a fan favourite at Old Trafford and has delivered the goods consistently.
In the big games, Herrera has done justice to the faith shown in him by the manager which was evident in the game against Chelsea. The nitpicky midfielder man marked Eden Hazard out of the game and will be employed to do the same against Alexis Sanchez.
Centre midfield: Paul Pogba (Manchester United)
After a slow and an inconsistent start, Paul Labile Pogba is slowly getting used to the demands of the Premier League. His recent performance against Celta Vigo in the Europa League was reminiscent of his Juventus days as the Frenchman completely bossed the midfield cauldron.
A similar type of work rate and execution will be needed against Arsenal as selecting Pogba is an easy choice over the underperforming Arsenal stars like Aaron Ramsey and Granit Xhaka.
Centre midfield: Alex Oxlade-Chamberlain (Arsenal)
This is a surprising inclusion in the midfield but a well-deserved one for Chamberlain. He has been one of the best Arsenal players this season and deserves a place in the lineup. He has been deployed at right back, in the midfield, as a number 10 and also as a winger in this season and "the Ox" has gone on to prove his worth wherever the team needed him to play.
He has started to come off age and has been playing like a matured player. From the midfield, Chamberlain can provide the necessary pace that is needed to give problems for the opposition.