Attackers:
Starter - RW - Jadon Sancho
Sancho is still unproven in an England shirt and being the only player in the squad plying his trade abroad, he needs as many minutes with the other English boys as possible.
Starter - STR - Callum Wilson
While Kane is head and shoulders above him in England's pecking order, rotating the squad to see if Wilson is a viable option up front for the Three Lions would be a smart move here.
Starter - LW - Callum Hudson-Odoi
The most talked about inclusion of Southgate's squad, Hudson-Odoi is somewhat of an unknown factor given how little time he has spent playing Premier League football. He looked solid in his brief stint against the Czech Republic and so Southgate should continue to introduce him to international football here.
Bench - Marcus Rashford
Rashford seems to be carrying a knock at the moment so should not be risked here.
Bench - Harry Kane
Kane is Southgate's striker of choice and is undoubtedly England's best number 9. Kane will only be the victim of experimentation from Southgate if he is to sit out on Monday.
Bench - Raheem Sterling
England's best player on Friday, Sterling again will only miss out on a starting spot if we do see significant reshuffling by Southgate.