Right-Wing Back - Callum Hudson-Odoi
After enjoying an extended run of matches in his preferred left-wing position, Callum Hudson-Odoi may need to fill in at right-wing back for this FA Cup clash. The winger was first used in the position by manager Thomas Tuchel in his first match in charge. He has since proven himself to be quite option useful in the position.
Hudson-Odoi will start the game because Reece James is still being eased into the team. According to Tuchel, James should have played only 20 minutes, but the injury to Azpilicueta forced him to play for up to 70 minutes. The right-back will have his minutes managed, and Hudson-Odoi will start at right-wing back here.
Central Midfield - Saul Niguez
Saul Niguez has not been used too often since joining the club on loan in the summer. This is due to his early struggles for form and consistency, as he failed to stake his claim for a starting shirt at Stamford Bridge.
Saul undoubtedly has the talent to thrive in London, as he has shown it in the past few matches he has played in. The Spaniard will look to help the club reach the quarter-finals of the FA Cup.
Central Midfield - Jorginho
Jorginho has been left out of the starting line-up for the last few games, with Tuchel claiming that the Italian international was mentally exhausted. The Italian came off the bench as a substitute for Mateo Kovacic in extra time against Liverpool on Sunday.
Jorginho will be looking to build up his rhythm by getting good minutes in this FA Cup fifth round clash. The midfielder will be key to helping his side dominate the midfield in the match.
Left-Wing Back - Kenedy
As news of the severity of Ben Chilwell's injury emerged, the club weighed their options for cover in his position. They eventually recalled Brazilian midfielder Kenedy from his loan spell at Flamengo.
Kenedy has not played a minute of football since January, and this FA Cup tie will represent the best chance to ease him into the team. Marcos Alonso has played a lot of football in recent weeks, and Tuchel will not want him to pick up an injury.