Right-back: Cesar Azpilicueta (Spain)
He has not been the most eye-catching player for Spain, but Cesar Azpilicueta remains a key member of Luis Enrique's squad.
His wealth of experience and big-game pedigree will come in handy in a game like this. Azpilicueta was on target against Croatia in the last-16, demonstrating his offensive aerial strength.
Centre-back: Leonardo Bonucci (Italy)
One half of Italy's colossal centre-back partnership, Leonardo Bonucci, hasn't put a foot wrong at Euro 2020 so far.
He is solid in tackling and possesses a good positional sense with equally impressive anticipation. The 34-year-old combines excellent technique and passing range to launch attacks from the back, making him a supreme all-round defender.
Centre-back: Giorgio Chiellini (Italy)
Here's another of Italy's old guards. Chiellini is 36 but is still producing impressive performances for Italy at Euro 2020, complementing his partner Bonucci well.
The Juventus veteran has been a leader of Italy's defence, often seen signalling to his teammates. He has averaged three clearances per game in the competition.
Left-back: Jordi Alba (Spain)
Who says Jordi Alba's best days are behind him? He has been a revelation with Spain at Euro 2020, contributing immensely to their attack with inch-perfect crosses and creating four big chances.
His tireless forward runs have been key to stretching defences wide. Alba also forced an own goal against Switzerland, another testament to how dangerous he can be in offence.