#4 vs Bayer Leverkusen (2012)
In 2011-12 champions league season, Barcelona met German side Bayer Leverkusen in the round of 16 and it is fair to say that Spanish side was too much for Bayer Leverkusen. In the second leg at camp now, the world witnessed yet another sensational display by Lionel Messi as he scored 5 goals in a match- his first 5 in a match till then.
The Argentine was at his prolific best and started the scoring for Barcelona with a classic Lionel Messi chip goal and thus began Leverkusen's traumatic journey. The Barcelona number 10 notches up 4 more goals to score 5 as Barcelona comfortably dispatched their German opponents 7-1 and 102 on aggregate to progress to the quarterfinals.
This is the only time Lionel Messi scored 5 goals in a champions league tie making it all the more special.