#1 vs Arsenal (2010)
In 2010 Arsene Wenger and his Arsenal side went to Camp Nou for the second leg of their quarterfinal match against Barcelona. With the scores settled in the previous encounter (2-2), Arsene Wenger had some hope going into the second leg but little did he know that a little genius is waiting for his side there.
Lionel Messi put all arsenal hopes to bed as we witnessed one of the finest individual performances in Europe's' elite club competition. Arsenal took the lead early on as Nicklas Bendtner scored to put the visitors ahead but then on it was Lionel Messi spectacle as the Argentine took the centre stage and score 4, yes 4 goals to take his side to the semi-finals.
Manuel Almunia will never forget the day Lionel Messi humiliated the entire arsenal as he scored 4 past the retired Spanish goalkeeper. The Argentine scored a hammer from his majestic left foot to open the scoring before adding one more minute later and just before halftime we witnessed a classic Lionel Messi chip over the goalkeeper as the Argentine completed a sensational first half hattrick.
To this date, it remains one of Lionel Messi's great hattricks and one of the greatest ever scored in the UEFA champions league.