Right-back - Kyle Walker (Manchester City)
Liverpool's Trent Alexander-Arnold has redefined the role of a modern full-back with his imperious attacking prowess. But as he's set to miss the clash against City with an injury, Manchester City's Kyle Walker gets the nod.
Sure, he ain't as menacing going forward as Alexander-Arnold, but Walker makes up for that with his astute defending. Walker has won six aerial duels, made 16 ball recoveries and completed 93.1% of his passes in the Premier League this season.
Centre-back - Ruben Dias (Manchester City)
A revelation in the Premier League last season, Ruben Dias has had a transformational impact on Manchester City's defence last season. Since arriving from Benfica, he has provided the basis for them to launch a successful title assault.
Dias is known for his astute passing prowess (he leads the Premier League this season with 493), strength on the ball and leadership skills. He has brought a lot of silk and steel to City's backline, making them a mean outfit. He could be the key to stopping Liverpool's in-form attackers like Mohamed Salah and Sadio Mane.
Centre-back - Virgil van Dijk (Liverpool)
Another defender who's had a major impact for his side, Virgil van Dijk has rejuvenated Liverpool's defence since arriving from Southampton. His importance was laid bare last season, as the Reds struggled mightily in defence, and their title defence spectacularly imploded without him.
Now back fit and firing again, the Dutchman has looked like he was never absent. Van Dijk has added the composure and steel the Reds desperately lacked since his injury early on in the 2020-21 season.
Left-back - Andrew Robertson (Liverpool)
The Scotsman's rise to the upper echelons of the footballing pyramid has been quite remarkable. Andrew Robertson arrived at Liverpool as a promising young full-back from Hull City before quickly becoming the most talented player in his position.
His crossing ability is second to none. Robertson has racked up assists at a blistering pace, while also playing a key role in creating attacking plays for Liverpool with his passing and movements.