This will be the 229th occurrence of the biggest fixture in the English domestic season calendar, with 20-time English champions, Manchester United, taking on 18-time English champions, Liverpool, at Anfield.
Both teams approach the match with different results in the midweek, as Liverpool nudged past Napoli by a lone goal to enter the knockout stages of the Champions League, while an already qualified Manchester United lost 2-1 to LaLiga side, Valencia.
The Merseysiders are on their best ever start to a domestic season, with the team yet to lose a single league match so far. The Reds have won an impressive 6 of their last 7 matches, and lead the Premier League table by a single point.
Manchester United are 16 points behind their arch-rivals, with the Red Devils only managing a single victory from their last 5 away matches.
Liverpool vs Manchester United: Kick-off information
Date: 16 December 2018
Time: 17:00 (local time), 21:30 (IST)
Venue: Anfield, Liverpool
Livestream: Hotstar
Liverpool vs Manchester United: Team news
Jurgen Klopp will have to reshuffle his defensive line-up, with Joe Gomez, Trent Alexander-Arnold, and Joel Matip all missing out through injury. Nathaniel Clyne might make his first appearance in the league this season, and Jordan Henderson is set to return to the starting line-up after missing the last 3 matches due to suspension.
Jose Mourinho has 9 first team players on the treatment table, with Marcus Rojo, Victor Lindelof, and Alexis Sanchez ruled out. Meanwhile, Chris Smalling, Diogo Dalot, Matteo Darmian, Luke Shaw, Scott McTominay, and Anthony Martial are all doubts for the fixture.
Liverpool vs Manchester United: Probable line-up
Liverpool: Alisson, Milner, Lovren, Van Dijk, Robertson, Henderson, Keita, Wijnaldum, Salah, Mane, Firmino.
Manchester United: De Gea, Young, Bailly, Smalling, Jones, Shaw, Matic, Herrera, Lingard, Rashford, Lukaku.
Liverpool vs Manchester United: Form guide
The last 5 competitive matches
Liverpool: W-W-W-W-L
Manchester United: L-W-D-D-W
Liverpool vs Manchester United: Head to head
Liverpool: 75 wins
Manchester United: 88 wins
Draw: 65
Liverpool vs Manchester United: Prediction
The home side is yet to drop points in the league at home this season, with Anfield proving to be a fortress for the Reds. The attacking trio of Mane, Salah, and Firmino are yet to reach the stellar heights of last season, but the return to form of Mo Salah is sure to strike fear into the hearts of the opposition defenders. Their defense has so far been very effective, with 10 clean sheets in the season so far.
Manchester United though are not a team to bow down, with Mourinho being a master of the big matches. The quality within the Manchester United ranks can bring hell upon any defence, but it is impossible to predict which Manchester United side will turn up on the day.
Prediction: Liverpool 2-1 Manchester United