#3 Alexis Sanchez vs Kieron Trippier
It appears likely that Mauricio Pochettino will trust the more reliable Trippier over the more exciting, but oh, so unreliable Serge Aurier down the right flank and that will put him in direct contact with the utterly underwhelming Alexis Sanchez.
To be fair to the Chilean, and it seems to be a crime to be that, he's just settling into a new team - with a new manager who plays football that is as unlike his previous manager as possible - and he seems to be finding his feet. Trippier, meanwhile, has stepped into Kyle Walker's shoes brilliantly and has been great defensively - and offensively - this season.
How Sanchez handles Trippier will be extremely important to the match. But it's not just in offense that the Chilean has to sparkle.
With Pochettino's narrow midfield and forward line, Trippier's importance in Spurs' offensive strategy is paramount - and Sanchez will have to do his bit in tracking back as well.