#3 Fitness of Goal-hungry Harry Kane
This man can't stop scoring at the moment. Harry Kane has been in stunning form this season and tops the scoring charts in Premier League (8 goals) and UEFA Champions League (5 goals).
But on Thursday, Pochettino confirmed that Harry Kane is a doubt for the all-important Manchester United clash. He suffered a thigh injury against Liverpool and did not play a part in the midweek Carabao cup tie. Kane is the fulcrum behind Tottenham's recent success and his absence will certainly have a huge impact on the result.
Kane is the focal point of Tottenham's attack play and his absence will be a relief to United defenders and a problem for Pochettino. With Dele Alli not in great form, Tottenham will find it hard to breach the Old Trafford fortress.