#2 Manchester United 1-2 Sevilla (UEFA Champions League, 13 March 2018)
United's Champions League were dramatically murdered by a quick-fire double by Sevilla substitute Wissam Ben Yedder.
Form before the match
With their exit from the Carabao Cup in December and a near-impossible task of catching up with City in the Premier League, United's only hope of saving their season was by winning the remaining two cups - the less important FA Cup and the higher priority UEFA Champions League.
The first leg of the Round of 16 clash in the UCL had ended in a drab 0-0 draw with Sevilla the better side. However, with home advantage, United was hoping for a routine victory which would take them to the quarter-finals of Europe's elite competition.
How did the match progress?
A 0-0 draw isn't always a good result to bring back home. Even a 1-1 draw at Old Trafford would seal United's exit from the competition. Perhaps, the anxiety had a good effect on the players as United started the game brightly.
Despite their lowly fifth position in La Liga at that time, Sevilla is a dangerous side and their constant threats to the United goal showed this.
United's failure to get a goal early on proved to be disastrous, as a minute after his introduction, Sevilla striker Wissam Ben Yedder drove a low shot past David de Gea that stunned Old Trafford.
With two goals needed in 18 minutes, Mourinho sent on Mata and Anthony Martial but before they could make an impact, Ben Yedder struck again, this time with a header. United tried to stage a spirited comeback after Lukaku's goal but it wasn't to be.
How did it impact United?
With the Premier League title out of reach, winning the UEFA Champions League trophy would have been more than a consolation for Jose Mourinho's side.
Despite the signing of Alexis Sanchez from Arsenal in the mid-season transfer window, the team was criticized relentlessly by fans and pundits alike.