Mauro Junior's acrobatic volley for Heracles against FC Twente
Aitor Cantalapiedra gave the home side the ideal start with a goal after just five minutes - with VAR ruling out a second from Javier Espinosa.
That decision proved costly for Twente with Heracles scoring twice at the end of the first half through Cyriel Dessers and a brilliant Mauro Junior volley.
Junior then scored Heracles' third goal and despite a stoppage-time header from substitute Emil Berggreen, Twente had lost for the first time this season.
As a result of their win, Heracles move up to fifth, just a point behind Twente.