Right-back: Trent Alexander-Arnold
Trent put up a disappointing showing against Crystal Palace as his inexperience often left him exposed. With the preferred right-back, Joe Gomez, injured during England friendlies, Trent has been ordered to step in. Nathaniel Clyne who has been out for almost the whole season has recently made a return, however, he may not be fit enough to start against Manchester City.
Centre-back: Joel Matip
The Liverpool centre-back missed the last two Champions League games after suffering two separate injuries. Having returned to the starting line-up against Crystal Palace, Matip is certain to partner Virgil van Dijk against their Premier League rivals, Manchester City.
Centre-back: Virgil van Dijk
The Dutch defender started one Champions League match and was on the bench for the other. Against Manchester City, Liverpool are in need of a responsible defender who can manage the backline. The January record signing played no part in the Premier League clash between Liverpool and Manchester City due to a thigh injury, however, for this upcoming match, Van Dijk is expected to play the full match.
Left-back: Andrew Robertson
Robertson impressed the fans and his team-mates during the game against Crystal Palace. His creativity and collaboration with Salah proved to be effective. Klopp could place his trust in the Scottish to do his job in Champions League.