Forwards
Alexis Sanchez (LW)
Alexis Sanchez showed flashed of his old self against Crystal Palace and he might get another start as Anthony Martial is still injured. The Chilean has to start performing now or else he may drop even further down the pecking order and be offloaded in the summer.
Romelu Lukaku (ST)
Romelu Lukaku scored two goals against Crystal Palace and showed that he still has a lot to offer to the Red Devils. He might get a nod ahead of Marcus Rashford as Solskjaer wouldn't want to rush the Englishman back from his injury.
Andreas Pereira (RW)
Andreas Pereira was on the bench against Crystal Palace and he may get a go against Southampton as Solskjaer has to rest his key players before the Champions League. Pereira was brilliant against Liverpool and he may get another shot at impressing his Norwegian boss.