#4 Wolves vs. Tottenham
Wolves have impressed many with their style of play. Nuno Espirito Santo's men have taken points against both the Manchester clubs this campaign. They were on an unbeaten streak, but defeats in the last two fixtures against Watford and Brighton have pegged them back a bit. However, the team has enough in them to cause an upset against Spurs.
Mauricio Pochettino would agree that Tottenham Hotspur hasn't been impressive this season. Spurs need a miracle to qualify from the group stages in the Champions League while the last weekend's defeat against Manchester City in the Premier League highlighted the issues the club is facing at the moment.
Prediction: Wolves 1 - 2 Tottenham Hotspur
#3 Manchester City vs. Southampton
Manchester City is in a different league at the moment. Pep Guardiola's side is looking like an unstoppable force and is well on their way to win the league for the second time in a row.
The Saints are just two points above the relegation zone and have only won one game so far this campaign. Mark Hughes's side is struggling to get a good string of games under their belt, and a game against City might be the last thing they would have wanted at this moment.
Prediction: Man City 4 - 0 Southampton