Striker: Harry Kane
Despite missing four games due to torn ankle ligament, Kane finds himself very much in the race for another Premier League Golden Boot with 15 strikes in 24 appearances.
Even though Spurs have lost both games since his arrival, Kane's return couldn't have come sooner given his impressive record in the derby.
Since 2014/15 season, the English hitman has scored in seven of the eight league meetings, netting eight times in all. The last of it came in the 4-2 loss at the Emirates in December but assisted on his return there for the FA Cup clash. In fact, Arsenal is his favourite side among the top six teams as they often tend to bring out the best in him.
Omens are really bad for the visitors.
Striker: Pierre-Emerick Aubameyang
Ostracising Alexandre Lacazette, who has struck 12 times in the league, would seem quite unfair. But his Gabonese attacking counterpart has been firing at all cylinders in his first full season with Arsenal.
With 16 goals from 24 appearances, Aubameyang trails only Sergio Aguero and Mohamed Salah in the scoring charts and also has another four assists to his name.
A particular criticism against the former Borussia Dortmund striker is his tendency to come to a cropper against the big sides, having struck only twice in 11 appearances against the other teams from the big six.
However, both those goals came against Spurs in the 4-2 comeback victory earlier in the season.
Arsenal needs their target man to step up again in a crucial game like this one.