2: Everton 1-6 Arsenal, 2009/10
Back in 2009, Arsenal were still considered to be a team who could challenge for the Premier League title, and their opening day demolition of Everton at Goodison Park certainly didn't damage their odds.
The two teams had finished fourth and fifth at the end of the previous season, but they looked worlds apart in what was one of the most comfortable opening day victories of all time.
Granted, Everton defender, Joleon Lescott was in the midst of a move to Manchester City, but that's still no real excuse for the total collapse of the whole Everton team.
Arsenal grabbed themselves goals through Denilson, Vermaelen, Gallas, Eduardo, and a brace from Cesc Fabregas, while Louis Saha scored perhaps the most pointless goal of his career for Everton in the 92nd minute, the very definition of a consolation strike.
Arsenal would go on to finish third that season, while Everton finished eighth, missing out on a spot in Europe to Liverpool by two points.