Central midfielder - Danilo Pereira
Despite having one of the best squads in the world, PSG are spread unexpectedly thin in the middle of the park. Ander Herrera, Marco Verratti and Giorginio Wijnaldum are all expected to miss the tie, giving Pereira another shot at impressing his PSG boss.
The Portuguese midfielder is not the most versatile midfielder, but he adds a lot of steel to PSG's midfield. With him sitting in the middle, Nice are not expected to overpower the midfield, not with ease at least.
Pereira represented PSG against Saint-Etienne and put on a respectable show. He won four ground duels, made four tackles and finished the game with 100 percent passing accuracy.
All in all, it was an impressive shift from the experienced midfielder who is expected to produce something similar against Nice on Wednesday.
Defensive midfielder - Idrissa Gueye
With Neymar and Mauro Icardi ruled out, PSG are set to deploy Angel Di Maria as a winger. The switch could see Idrissa Gueye act as a lone defensive midfielder, shielding PSG's backline.
The former Everton midfielder is an expert at winning ground duels, can tackle well, and is also a great dribbler. The aforementioned traits were on full display in PSG’s previous outing against Saint-Etienne. In his 75-minute stint, Gueye made three key passes, completed three dribbles and won seven duels.
His performance in PSG’s last match should earn him a place in the starting XI against Nice and the Senegalese is not likely to disappoint.
Central midfielder - Leandro Paredes
On his day, Leandro Paredes can give any midfielder a run for his money. He is agile, technically gifted, and is blessed with excellent game-reading skills.
Unfortunately, niggling injuries have kept him from fulfilling his potential at PSG.
Paredes has missed six matches this season alone due to fitness and injuries, which has badly disrupted his flow. Paredes made a cameo appearance off the bench in the 3-1 win over Saint-Etienne and looked at ease.
Considering PSG’s lack of options in midfield, Paredes could end up making his fifth Ligue 1 appearance for PSG on Wednesday. Paredes' connection with compatriot Messi should also come in handy when charging ahead.