#1 Ferdinand and Vidic

There can be no such list of the best centre-defensive partnerships in the world without the inclusion of Rio Ferdinand and Nemanja Vidic. They are probably the best defensive pair Manchester United had in their entire history. Both of them were no-nonsense defenders who bought their A-game in many matches they played together at Old Trafford.
Vidic and Ferdinand formed a defensive shield in front of the Red Devils goalkeeper Edwin Van der Sar which was difficult to penetrate for the opposition attackers. Together they won 5 Premier League and 1 Champions League titles for Manchester United. Both were extremely good in the air and hence posed a great threat to the opposition from corners.
Hence, Vidic and Ferdinand formed a formidable defensive partnership for Manchester United.